How does minoxidil reverse miniaturization




















There are a number of natural and clinical treatments you can try. Eating a healthy diet that includes…. Healthline's picks for the best treatments for hair loss for men include Rogaine, Propecia, and more—how do they measure up? Want to give your mane a boost? Try these products to get shiny, healthy locks. HairMax is a company that specializes in laser light therapy to target hair loss — but do the devices actually work? Propecia otherwise known as generic Finasteride is typically used to treat male pattern baldness—but does it actually work?

Health Conditions Discover Plan Connect. Not only that, but the patient will be left with scarring in the donor area from donor hair harvesting without the cosmetic benefit of transplanted permanent hair. That is why at Bernstein Medical, we only recommend hair transplants in patients 25 years old or older. Since DHT is the main cause of male pattern baldness, why not develop a way to prevent DHT from causing miniaturization?

That is exactly what happens with the medication Propecia finasteride. With lower levels of DHT in the bloodstream, fewer follicular units are exposed to the miniaturizing effects of DHT, and they continue to produce healthy, thick terminal hairs. Rogaine , a topical over the counter medication for hair loss, also counter-acts the effects of DHT, but goes about it in a totally different way.

DHT shortens the growth phase of the hair cycle, leading to progressively smaller and finer hairs. The active drug in Rogaine, called minoxidil, works by lengthening the growth phase of the hair cycle. The result is fewer follicular units that experience miniaturization. See below for three examples of different intensities of miniaturization: the permanent zone with little to no miniaturization, moderate miniaturization, and extensive miniaturization.

In the following patient, we see a close-up of the side of his scalp where the hair is not affected by DHT.

We see mostly groups of full-thickness hairs called terminal hairs and a few scattered, fine vellous hairs, normally seen in a donor area. There is no effect on blood pressure when applied as directed. Clinical studies were run during which some men and women with pattern hair loss applied Rogaine topical lotion to their scalps, and others with pattern hair loss applied the same mixture of water, alcohol, and propylene glycol used in Rogaine lotion, but without the minoxidil a placebo.

The men and women selected for the study had thin hair or baldness on the top of their heads, where minoxidil is most effective at promoting hair regrowth. The effectiveness of the minoxidil treatment was compared to the placebo lotion. The results of clinical studies involving thousands of men and women have shown Rogaine topical lotion is able to cause statistically significant increases in hair regrowth. Minoxidil treatment does not work on everybody with thinning hair due to inherited pattern hair loss.

It is less effective for hair loss at the hairline than on the top of the head. It is less effective on large bald spots than small ones. It is less effective on small bald spots than on diffuse thin areas. It is less effective on long-established baldness than recent hair loss. Minoxidil treatment is not a permanent cure.

It must be applied twice-daily for as long as the newly regrown hairs are desired to be retained. It requires commitment. Those treating their hair loss with minoxidil have to think about treating their hair loss every day. Skipping a day or two occasionally is not likely to cause any measurable difference in the effectiveness of minoxidil treatment. However, after several months of discontinued use, the regrown hairs are likely to be shed.

Also, the hairs that would have been shed if the minoxidil had not prevented follicle miniaturization will also be lost as those follicles begin to shrink. Regrown hairs may be shed within just a few months after discontinuing use of minoxidil.

Although Rogaine topical lotion is a colorless, odorless, and non-greasy liquid that dries quickly and without any visible residue, some people simply do not like putting lotions on their scalp.

Betamethazone valerate is a cortisone medication that helps to prevent scalp inflammation. Blocking this signal may keep more hairs growing. Second, betamethazone valerate helps to disperse the white blood cells that are called up to push the hair shaft out of the hair follicle. Limitations of Minoxidil However, Minoxidil does not work on areas of the scalp that has grown completely bald, as this suggests that the opening of the hair follicles have closed completely.

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