Shopping Cart Your cart is empty. Log In. Xiang Sha Liu Jun Wan. When your appetite is poor and you suffer from diarrhea, loose stools, indigestion, nausea, gas, or chronic diarrhea, try it to regulate the flow of Qi to alleviate pain and to reduce phlegm and dampness so you can get back to everyday living. Xiang Sha Liu Jun Wan is the ancient Chinese herbal medicine, which has been successfully used for several centuries to treat diseases of the digestive system. Recipe for this unique remedy is known since the times of the Qing dynasty, and its description is first encountered in the scientific work "The Golden Mirror of Medicine".
Pharmacological action: improves digestion by enhancing the secretory activity of the digestive glands, normalizes the work of the endocrine system, it has a special effect on the functioning of the thyroid gland and cortical adrenal gland, promotes immunity strengthening, participates in the synthesis of nucleotides and their cyclic reactions.
Action according to traditional Chinese medicine: the pathology of the digestive system and the spleen begins to progress with accumulation in the average heater of dampness and cold.
Xiang Sha Liu Jun Wan is able to influence the internal energy of Qi, improve the work of the intestines, stomach, digestive glands and spleen, so that the symptoms of the disease gradually fade and person recovers. Xiang Sha Liu Jun Wan Indications for use: Pathology of the digestive system with a violation of the acidity of gastric contents. Dysfunction of the digestive glands. Inflammatory liver disease. Odds ratio was used to assess the change of dyspeptic symptoms in patients with functional dyspepsia.
Table 2 shows the OR and summary OR for each trial. The summary OR was 1. One trial which was performed in Japan provided data of plasma acylated ghrelin [ 20 ]. The baseline of acylated ghrelin had no significant difference between two groups. The studies were all performed in China. The duration of treatment was 4 weeks. Eight trials reported effects in favor of XSLJZT compared with prokinetic agents at the end of treatment [ 13 — 17 , 22 , 25 , 26 ], while one trial reported negative result [ 21 ].
A meta-analysis of the nine trials showed a significant increase of symptom improvement over prokinetic drugs odds ratios 2. However, the number of studies was improper to produce a meaningful funnel plot. Of the 15 RCTs, twelve trials did not mention the occurrence of adverse events. Fan [ 16 ] and Arai et al. Tian and Wang [ 27 ] reported that 16 out of 80 patients had experienced a variety of symptoms including abdominal pain, diarrhea, rugitus, and loose stools in the prokinetic drugs group.
These symptoms could be tolerated by patients. Based on the meta-analysis of 15 randomized controlled trials, it can be documented that both Xiang Sha Liu Jun Zi Tang and Liu Jun Zi Tang are more effective than prokinetic drugs for patients suffering from functional dyspepsia. Experimental data has demonstrated that LJZT may be thought to improve functional dyspepsia by reversing the existing impaired adaptive relaxation, leading to an improvement in delayed gastric emptying and stimulation of ghrelin secretion [ 29 — 31 ].
XSLJZT can significantly improve electrogastrogram, promote gastrointestinal motility and gastric emptying, decrease gastric sensitivity, and regulate gastrointestinal hormone [ 32 — 35 ]. Pharmacological studies have shown that ginseng radix and pinelliae tuber can accelerate gastrointestinal motility and cause increases in intestinal propulsion [ 36 , 37 ]. Hoelen could be applicable for the treatment of functional dyspepsia by regulating gastric movement through its facilitatory effect on efferent discharge of the gastric vagus nerve [ 38 ].
Atractylodes macrocephala koidz can improve the delayed gastric emptying and promote gastrointestinal motility [ 39 ]. Isoliquiritigenin plays a dual role in regulating gastrointestinal motility, both spasmogenic and spasmolytic [ 40 ]. Costusroot has been demonstrated to shorten the time of gastric emptying and increase plasma motilin concentration [ 41 ].
The safety profile of LJZT and XSLJZT appears satisfactory, both in view of the data derived from clinical and observational studies and considering the fact that the drugs have been prescribed for patients with functional dyspepsia for hundreds of years in China. The explanation of the encouraging safety might be that the multitarget effect of herbal preparations may produce relatively low concentration of active ingredients.
In this meta-analysis, there were several limitations. No multicenter, large sample, and cooperative studies were found, and most of the trials were of small sample size, yet no studies estimated the sample size. Among all 15 articles, 2 applied random number tables [ 16 , 17 ]; the remaining 13 studies did not provide the method of randomization procedure.
Due to inadequate reporting of the allocation sequence, we cannot draw a judgement of whether or not they had been conducted properly. And inadequate reporting of allocation concealment, blinding, dropouts account, and intention to treat analysis in all the studies may have created potential selection biases, performance biases, and detection biases.
Although we conducted comprehensive searches and tried to avoid bias, since most of the trials were published in Chinese, there remained the possible existence of publication bias.
However, the general quality of the reports was moderate to low, and most of the trials were published in Chinese. Therefore, the effectiveness of LJZT and XSLJZT needs further evidence of rigorously designed, multicentre, large-scale, and transnational cooperative RCTs to prove, which would contribute greatly to the treatment of functional dyspepsia worldwide.
This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article of the Year Award: Outstanding research contributions of , as selected by our Chief Editors. Read the winning articles. Journal overview.
Special Issues. Academic Editor: Il-Moo Chang. Received 09 Aug Revised 15 Oct Accepted 26 Oct Published 12 Dec Abstract Objectives. Introduction Functional dyspepsia, also known as nonulcer dyspepsia, is defined as persistent or recurrent abdominal pain or discomfort centred in the upper abdomen in the absence of an identifiable organic disease for at least a month [ 1 — 3 ].
Methods 2. Data Abstraction Two researchers abstracted the data from the studies independently to avoid bias in the data abstraction process. Data Analysis Meta-analysis was carried out using Review Manager software version 5.
Results 3. Description of Included Trials A total of 51 publications were identified by both computer search and manual search of cited references. Figure 1. Table 1.
Table 2. Table 3. Table 4. References G. Karamanolis, P. Caenepeel, J. Arts, and J. Kusunoki, K. Haruma, J. Hata et al. Lacy, N. Talley, G. Webmail Log in. Min Shi, Ph. It is used for deficiency of Qi of the spleen and stomach, retention of cold —dampness in the middle-Jiao, anorexia, belching, abdominal distension or pain, vomiting and diarrhea. Traditional preparation procedures are combined with modern pharmaceutical processes to extract the active ingredients from the herbs and to further concentrate them into pills or tablets.
How to use it? Cautions: 1. Do not take during pregnancy.
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